Clorazepate Dipotassium, USP

Trademarks and Copyright© The images and information contained in the Site are, to the fullest extent possible, copyrighted and otherwise proprietary. It is the policy of Taro to enforce its intellectual property rights to the fullest extent of the law, including (where applicable) seeking criminal sanctions.

Taro Products -

Quick products selector

Clorazepate Dipotassium, USP

7-Cloro-2,3-dihydro-2-oxo-5-phenyl-1H-1, 4-benzodiazepine-3-carboxylic acid
Dipotassium Salt

C₁₆H₁₁Cl K₂N₂O₄
Mol. Wt.: 408.93
CAS 57109-90-7

Description
Off-white to light yellow crystalline powder.

Solubility
Soluble in water, slightly soluble in ethanol and 2-propanol, almost insoluble in chloroform, ether, acetone and methylene chloride.

Identification

IR Spectrum: conforms to that of USP standard.
Ultraviolet absorption: The ultraviolet spectrum conforms to that of USP standard.

Loss on Drying
Not more than 0.5%.

Heavy Metals
Not more than 20 ppm.

Assay
98.5% - 101.5% (calculated on dried basis)

Storage
Keep in a well-closed container. Protect from light.

Medical Use
As tranquilizer, anxiolytic.

Related Compounds

TLC
- No secondary spot is larger or more intense than the principal spot obtained from standard preparation (NMT 0.5%).
- Any violet-coloured spot is not greater in size or intensity than the principal spot obtained from standard solution B (0.1%).
- Total impurity spot: NMT 1%.
HPLC
- 7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepine-2-one impurity is less than 0.4%.
- 2-Amino-5-chlobenzophenone impurity is less than 0.1%.

Method of analysis is available on request.