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Warfarin Sodium Clathrate USP

Warfarin Sodium Clathrate USP

 Warfarin Sodium Clathrate USP

4-Hydroxy-3-[3-oxo-1-(R,S)- Phenylbutyl]-2H-benzopyran-2-one, sodium salt, 2-propanol clathrate
 
C19H15NaO41/2(C3H8O)
Mol. Wt.: 330.32 + 30.05
CAS 67430-45-9
 
Description
White to off-white crystalline, odorless hygroscopic powder.
 
Solubility
Very soluble in water, soluble in methanol, ethanol, acetone. Very slightly soluble in 2-propanol, ether and methylene chloride.
 
Melting Range
Above 300°C with decomposition.
 
pH of 1% Solution
7.2-8.3
 
Water Content (Kf Titration)
Not more than 0.3%.
 
Colour Test (Absorbance In Alkaline Solution)
The absorbance ites not exceed 0.1 AU.
 
Assay
97.0-102.0% (on the anhydrous and 2-Propanol - free basis).
 
Related Compounds
Individual known - not more than 0.3%
Individual unknown - not more than 0.1%
Total - not more than 1.0%.
 
2-Propanol Content
8.0-8.5%
 
Storage
Keep in well-closed containers, protected from light.
 
Medical Usage
As anticoagulant, may prevent blood clotting and strokes.
 
Method of analysis is available on request


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